Pyridazines and derivatives
Aobchem 1-(4-Fluoro-3-isopropylphenyl)-2-methylpropan-1-one | 95% | C13H17FO | 1g
1-(4-Fluoro-3-isopropylphenyl)-2-methylpropan-1-one | 95% | C13H17FO | 1g
Aobchem 1-(4-Chloro-3-isopropylphenyl)-2-methylpropan-1-one | 97% | C13H17ClO | 1g
1-(4-Chloro-3-isopropylphenyl)-2-methylpropan-1-one | 97% | C13H17ClO | 1g
Accela Chembio Inc 5-chloropyridazin-3(2h)-one | 1g | 660425-07-0 | MFCD12198134 | 97+% | Shelf Life: 900 Days | Light Sensitive/n2/+4
5-chloropyridazin-3(2h)-one | 1g | 660425-07-0 | MFCD12198134 | 97+% | Shelf Life: 900 Days | Light Sensitive/n2/+4
![eMolecules 6653-96-9 | Imidazo[1,2-b]pyridazin-6-amine | MFCD10698052 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502139044.JPG-250.jpg)
eMolecules 6653-96-9 | Imidazo[1,2-b]pyridazin-6-amine | MFCD10698052 | 1g
Ambeed | Imidazo[1,2-b]pyridazin-6-amine | 1g | 552624062 | A181962 | 6653-96-9 | MFCD10698052 | 134.142 | C6H6N4
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eMolecules 64882-65-1 | 3-oxo-2,3-dihydropyridazine-4-carbonitrile | MFCD11040159 | 1g
Pharmablock | 3-oxo-2,3-dihydropyridazine-4-carbonitrile | 1g | 551283856 | PBTEN23331 | 64882-65-1 | MFCD11040159 | 121.099 | C5H3N3O
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![eMolecules 1948237-23-7 | [6-(trifluoromethyl)pyridazin-3-yl]methanamine;hydrochloride | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502159877.JPG-250.jpg)
eMolecules 1948237-23-7 | [6-(trifluoromethyl)pyridazin-3-yl]methanamine;hydrochloride | 1g
ChemScene | 3-Cyano-3-methylcyclohexanone | 100mg | 536835639 | CS-D1237 | 33235-14-2 | MFCD24688472 | 137.182 | C8H11NO
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eMolecules 1555847-27-2 | (4-METHOXYTETRAHYDRO-2H-PYRAN-4-YL)METHANAMINE HCL | MFCD26406717 | 1g
Medchem Express | MCL-1|BCL-2-IN-3 | 5mg | 506403963 | HY-129701 | 2163793-55-1 | 569.470 | C27H25BrN2O5S
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Aobchem 7-Chloro-1(2H)-phthalazinone | ≥95% | CAS 60889-20-5 | C8H5ClN2O | 1g
7-Chloro-1(2H)-phthalazinone | ≥95% | CAS 60889-20-5 | C8H5ClN2O | 1g
Medchemexpress LLC Zardaverine | 101975-10-4 | C12H10F2N2O3 | 1 ML
Zardaverine is an orally active and selective PDE3/4 inhibitor with potent bronchodilator activity. It selectively inhibits the proliferation of HCC cells, inducing apoptosis and cell cycle arrest (G0/G1 phase). Zardaverine demonstrates good antitumor potential and is effective in bronchial relaxation and reducing inflammation in asthma.
- Targets phosphodiesterase (PDE) and apoptosis
- Pathway: Metabolic enzyme/protease and apoptosis
- Storage for powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 2 years, -20°C for 1 year
- Soluble in DMSO (25 mg/mL)
- Soluble in 10% DMSO, 40% PEG300, 5% Tween-80, 45% saline (≥ 2.08 mg/mL)
- Soluble in 10% DMSO, 90% corn oil (≥ 2.08 mg/mL)
- IC₅₀ target: PDE3, PDE4
Medchemexpress LLC Phthalazine | 253-52-1 | 130.15 | 25 G
Phthalazine (Standard) is the analytical standard for Phthalazine, designed for research and analytical applications. It functions as a substrate for human aldehyde oxidase 1, which can lead to the generation of Reactive Oxygen Species (ROS) and subsequent inactivation of the enzyme. This product is an organic heterocyclic compound containing nitrogen. It has demonstrated antitumor activity in various cancers, including blood cancer, breast cancer, colon cancer, lung cancer, and renal cancer.
- Analytical standard for various assays.
- Utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS.
- Exhibits antitumor activity against blood cancer, breast cancer, colon cancer, lung cancer, and renal cancer.
Medchemexpress LLC Zardaverine | 101975-10-4 | C12H10F2N2O3 | 50 MG
Zardaverine is an orally active and selective PDE3/4 inhibitor with IC50 values of 0.58 uM for PDE3 and 0.17 uM for PDE4. It exhibits potent bronchodilator activity and is effective in reducing inflammation in asthma. Zardaverine also shows antitumor potential by selectively inhibiting the proliferation of HCC cells, inducing apoptosis, and causing cell cycle arrest (G0/G1 phase).
- Orally active and selective PDE3/4 inhibitor
- Potent bronchodilator activity
- Effective in reducing inflammation in asthma
- Selectively inhibits proliferation of HCC cells
- Induces apoptosis and cell cycle arrest (G0/G1 phase)
- Antitumor potential
Aobchem 5-Fluoro-1(2H)-phthalazinone | ≥95% | CAS 23928-50-9 | C8H5FN2O | 500mg
5-Fluoro-1(2H)-phthalazinone | ≥95% | CAS 23928-50-9 | C8H5FN2O | 500mg
Apexbio Technology LLC Phthalazinone pyrazole 880487-62-7 5mg
Phthalazinone pyrazole (CAS 880487-62-7) is a potent selective and orally bioavailable inhibitor of Aurora-A kinase a member of the Aurora kinase family that regulates key processes in cell division Dysregulation of Aurora-A is linked to chromosomal instability and oncogenesis in various tumor types In vitro phthalazinone pyrazole demonstrates strong inhibition of Aurora-A kinase activity with an IC50 of 31 nM while showing minimal effect on Aurora-B kinase at concentrations up to 100 M It inhibits the proliferation of HCT116 Colo205 and MCF-7 cells with IC50 values of 7 8 2 9 and 1 6 M respectively This compound is utilized in research to investigate the role of Aurora-A in cell cycle regulation and cancer biology
TARGETMOL CHEMICALS INC GPI-1046 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.GPI-1046 is an immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. Purity 99.91%
Medchemexpress LLC 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate | 186452-09-5 | MFCD00953146 | 99.8% | 360.4 g/mol | C20H28N2O4 | 50MG
GPI-1046 is a small-molecule immunophilin ligand reported to have neuroprotective effects and to modulate glutamate transporter activity. It is supplied in small laboratory pack sizes, typically as a DMSO solution, for preclinical research use only.
- Chemical formula C20H28N2O4.
- Molecular weight 360.4 g/mol.
- CAS number 186452-09-5.
- Purity 99.8%.
- Available as solution in DMSO and multiple small pack sizes.
- Intended for preclinical research use only.